Back to Home11/13/2025, 6:05:53 AM

Stanford Medicine scientists tie lupus to a virus nearly all of us carry

27 points
3 comments

Mood

thoughtful

Sentiment

neutral

Category

science

Key topics

lupus research

autoimmune diseases

viral triggers

Debate intensity20/100

Stanford Medicine scientists have linked lupus to a virus that most people carry, sparking discussion about the role of stress and other potential triggers in the development of the disease.

Snapshot generated from the HN discussion

Discussion Activity

Light discussion

First comment

8h

Peak period

3

Day 1

Avg / period

3

Comment distribution3 data points

Based on 3 loaded comments

Key moments

  1. 01Story posted

    11/13/2025, 6:05:53 AM

    6d ago

    Step 01
  2. 02First comment

    11/13/2025, 2:28:45 PM

    8h after posting

    Step 02
  3. 03Peak activity

    3 comments in Day 1

    Hottest window of the conversation

    Step 03
  4. 04Latest activity

    11/13/2025, 10:42:00 PM

    5d ago

    Step 04

Generating AI Summary...

Analyzing up to 500 comments to identify key contributors and discussion patterns

Discussion (3 comments)
Showing 3 comments
randycupertino
5d ago
1 reply
I've worked in lupus research and one of the things rheumatologists have told me is they see it frequently triggered by the most stressful events in people's lives. So a divorce, eviction, moving, death of a parent or child.

https://hsph.harvard.edu/news/stress-trauma-lupus/

Fortunately great steps have been taken with diagnosis and awareness (it used to not only be hard to find but very stigmatized, lumped in with psycho-somatic disorders like fibromyalgia, long COVID and chronic lyme).

Personally I think the T-cell immune balance research is promising: https://www.prnewswire.com/news-releases/lra-awards-2025-lup...

as well as PARP inhibitors for precision medicine https://clinicaltrials.gov/study/NCT05966480

Car-T for lupus thus far has been a nothingburger (Cabaletta Bio, Nkarta, Kyverna, etc).

eaurouge
5d ago
1 reply
Kyverna claims to have achieved remission in clinical trials. Is that really a nothing burger?

https://lupus.bmj.com/content/11/Suppl_1/A109

randycupertino
5d ago
I'm not saying Car-T doesn't work for certain diseases, more that it's too complex and too expensive to operationalize and unsustainable to bring to mass-market. It may prove successful as a one-off for individual rich single-payer patients but cell therapy companies fail left and right because they repeatedly can't operationalize the treatment into a sustainable business model. It has promising data and potential for transformational results, sure just too many challenges exist thus far for anyone to demonstrate durability bringing an actual treatment to market without major technological and economic advancements. The infrastructure & manufacturing is too intense, it's just not a scalable business.
ID: 45911282Type: storyLast synced: 11/17/2025, 6:03:24 AM

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