Back to Home11/11/2025, 8:07:54 AM

Colon cancer is rising in young people and scientists got a clue about why

31 points
29 comments

Mood

thoughtful

Sentiment

mixed

Category

science

Key topics

colon cancer

young people

gut health

microbiome

Debate intensity40/100

A new study links childhood exposure to colibactin to rising colon cancer rates in young people, sparking discussion on potential contributing factors such as gut health, plastics, and lifestyle changes.

Snapshot generated from the HN discussion

Discussion Activity

Very active discussion

First comment

4m

Peak period

24

Day 1

Avg / period

14.5

Comment distribution29 data points

Based on 29 loaded comments

Key moments

  1. 01Story posted

    11/11/2025, 8:07:54 AM

    8d ago

    Step 01
  2. 02First comment

    11/11/2025, 8:12:04 AM

    4m after posting

    Step 02
  3. 03Peak activity

    24 comments in Day 1

    Hottest window of the conversation

    Step 03
  4. 04Latest activity

    11/12/2025, 3:12:45 PM

    6d ago

    Step 04

Generating AI Summary...

Analyzing up to 500 comments to identify key contributors and discussion patterns

Discussion (29 comments)
Showing 29 comments
nikolay
8d ago
1 reply
OutOfHere
7d ago
1 reply
I am getting a "Secure Connection Failed" error.
diogenes_atx
7d ago
1 reply
What is your DNS sever? You might try Cloudflare for DNS (1.1.1.1, 1.0.0.1), it has good privacy and works with archive.is
OutOfHere
7d ago
2 replies
I will never use Cloudflare. I use NextDNS.
jtokoph
7d ago
I’m also using NextDNS and haven’t been able to load any of these archive domains in at least a few days now
diogenes_atx
7d ago
Why are you so opposed to CloudFlare? It's not perfect, but definitely better than Google and most ISP's... You might try an experiment to see if you are able to reach the archive.ph domain with CloudFlare, if only to see if DNS is the problem.
Bender
7d ago
2 replies
Peoples exposure to E. Coli is not new. Something else changed in the last few years. What could it be?
4gotunameagain
7d ago
1 reply
Average number of sexual partners has skyrocketed for sure..

Diet and UPFs as well ? There are so many things that have changed.

Bender
7d ago
1 reply
Average number of sexual partners has skyrocketed for sure..

In the last few years? I would suggest it's much lower than it was in the 60's and 70's during the free love movements and other related movements. Prior to the 80's there was a lot more unprotected sex prior to the aids epidemic. Porn with a lot of body hair basically exploded when VHS tapes were created and people experimented a lot more.

Diet has certainly gotten worse. Most of the artificial crap was being introduced in the early 70's with a trailing 10 year lag on T2D increase but that has definitely gotten worse with time. What big change was introduced into the diet in the last few years?

4gotunameagain
7d ago
1 reply
I highly doubt that when they are talking about a rise in colon cancer they are talking in relationship to the 60s or 70s. And what does porn with body hair has to do with anything ? Your reply seems ideologically motivated.
Bender
6d ago
1 reply
I like the idea of this being ideologically motivated. To find what that may be I think we need to figure out what has changed in the last few years and then risk-rank each item to get started.
taschda
6d ago
The average number of sexual partners has changed considerably over the decades. Baby boomers (1946-1964) report an average of 11 partners, while Generation X (1965-1980) has an average of 10 partners. Millennials (1981-1996) have a lower average of 8 partners. The lower average number of sexual partners could lead to bowel cancer. Joking aside. I would suggest that the world has become a bitter place. Water quality, pollution, microplastics, air quality, factory farming (meat production in general, drug distribution, multi-resistant germs). Average meat consumption per day is rising. Everything is getting worse because humans are causing climate change, suffering of living beings and nature and refusing to change the status quo.
jmclnx
7d ago
1 reply
Diet. When I was younger than 16, we and everyone had home cooked meals every day, no choice. Places like McDonalds did not start showing up in my area when I was 12 or 13.

As time went on, divorce rates increased and/or both spouses were forced to work full time, meals gravitated towards fast and/or ultra-processed food. Why ? The parents had no time to cook.

So here we are.

I wish the article had rates based upon household income too. I kind of expect the children of the very rich is avoiding this trend because they could have servants/hired caregivers cooking for them.

Bender
7d ago
1 reply
That's an interesting idea however McDonalds has been around since 1940 even if it has not been available to you for very long. I think it must be something else.
moritzwarhier
7d ago
1 reply
While the comment is phrased like it could say that, I don't think that you are responding to the right point.

The point was that people eat fewer freshly prepared meals than before. And while I'm on the go, so I won't research a study, I'm pretty sure this is true.

Additional points:

- street food in Western countries is never really nourishing, almost exclusively fat, sugar, meat protein and processed white bread

- quality of fast food has gone down the drain on top of that, at least here

- not enough daily physical activity

- lots of stressful jobs without physical activity

Bender
7d ago
2 replies
I do get it. People have not been eating fresh foods since at least the 1970's. Fast food has been prevalent and popular since the 70's.

Something else changed in the last few years. One of these things is not like the other.

moritzwarhier
7d ago
Might be true, but I don't think malnutrition, sedentary lifestyle etc have peaked in the 70s.

If these factors are perfectly controlled for, maybe you're right. It would be stupid for me to further engage in discussion about it though, without having read science about this.

There are other things we know about though, for example an increase in microplastics intake.

jmclnx
7d ago
Plus do not forget, the article said the "damage" happens in the first 10 years of a child's life. So people born in the 70s are also seeing an increase in colon cancer.

BTW, for my main comment, I am probably in the top 15% of age distribution of people commenting here.

hypefi
7d ago
1 reply
A new object has been introduced that is near the area that emits EMFs constantly, guess what it is
nh23423fefe
7d ago
2 replies
how does non-ionizing radiation produce harm?
robocat
7d ago
Through the nocebo effect.
hypefi
7d ago
potential quantum biology effects
tsoukase
7d ago
1 reply
Possible factors: (micro)plastics, pesticides, excessive calories, excess fat or salt and, the elephant in the room, anxiety.

All impossible to test in a highly controlled environment.

fucjdn184
7d ago
1 reply
Or the other even bigger elephant, immune dysfunction due to repeated infections with SARS-Cov2.. wild how a large gray mammal hides in plain sight
tsoukase
6d ago
IMHO immune suppression or conversion is the rhino in the zoo. Sure there are many other wild mammals that are less heavy like nuclear and sun radiation, air pollution, sedentary way of life even electronic device usage. All with intermingling mechanisms that are buried in the cell division cycle.
aixpert
7d ago
Are we talking red bull age or younger?
OutOfHere
7d ago
Dysbiosis deserves 100x more attention as a cause of diseases. Beyond the gut, it even is a factor for heart disease. From its pov, we live in the dark ages.

Moreover, with increased antibiotic resistance, it could become harder to treat.

JumpCrisscross
8d ago
“A new study published in Nature has identified a strong link between childhood exposure to colibactin and colorectal cancer in patients under the age of 40.”

Study: https://idp.nature.com/authorize?response_type=cookie&client...

ID: 45885130Type: storyLast synced: 11/17/2025, 6:00:26 AM

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