Common Supplement [Melatonin] Shows Concerning Link to Heart Failure
Mood
thoughtful
Sentiment
negative
Category
science
Key topics
melatonin
heart failure
supplements
A study found a concerning link between long-term melatonin use and increased risk of heart failure, sparking discussion about the potential risks of common supplements.
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Discussion Activity
Light discussionFirst comment
36s
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Day 1
Avg / period
3
Based on 3 loaded comments
Key moments
- 01Story posted
11/7/2025, 6:41:00 PM
11d ago
Step 01 - 02First comment
11/7/2025, 6:41:36 PM
36s after posting
Step 02 - 03Peak activity
3 comments in Day 1
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Step 03 - 04Latest activity
11/7/2025, 8:31:26 PM
11d ago
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People who are prescribed melatonin have seen a doctor for sleep or other health disturbances.
Heart failure is strongly associated with sleep disturbances, see e.g.: https://www.nature.com/articles/nrcardio.2016.71
So all of this could be putting the cart before the horse. People who see the doctor for sleep issues -- or related health issues -- are more likely to die of heart failure for reasons that have absolutely nothing to do with their melatonin prescription in itself.
You've got to run an analysis in healthy people who take melatonin via unprescribed supplements or from dietary sources. I'd bet it finds no increased morbidity.
I'd also bet that you find increased morbidity in people who take other prescription soporifics.
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