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But seriously, there probably are a few people who can see genes from proteins like that, faster than a whole datacenter of GPUs. Putting together such a brain trust could be invaluable.
Making a nice-looking web GUI without knowing relevant vocabulary was a very clunky process in comparison to code pipelines, basically just pasting screenshots into the chat window and asking LLMs to "line up stuff properly", which they still couldn't manage to do in places.
I wonder if there's a way to ease the difficulty by filling in 'correct' features of the guesses: if your guess is a 'transmembrane' then it reveals that as a property. On the other hand, I don't think the annotations are clean enough - and are often designed for 'at all' rather than 'primary' features. For one of the examples, once I noticed it was an adhesion protein, it would have been interesting to sift through classes or cell types as opposed to just continuing to shoot in the dark based on the structure alone.
I presume you're showing even the 'low confidence' portions of the predicted structure? Please do.
You could also show the primary amino acid sequence too - there's a weird familiarity with those given how often the structures themselves have historically not been so accessible. BLASTING each of the guesses would be another interesting thing to see.
> I wonder if there's a way to ease the difficulty by filling in 'correct' features of the guesses Rather than allowing players to guess individual features, I opted for the "highlight" system where all hidden features that match your guessed protein's features get auto-revealed. This way, if you suspect a transmembrane protein, you can just guess a known transmembrane protein and see which features auto-reveal.
> it would have been interesting to sift through classes or cell types You're welcome to suggest databases with good coverage over the proteome that I could use for these.
> I presume you're showing even the 'low confidence' portions of the predicted structure? Yes, any residues in the files I fetch get rendered. I rank by coverage before fetching.
> You could also show the primary amino acid sequence too I'll consider it.
GeneGuesserIt
You could start with popular gene names.
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