Serial Ketamine Infusions as Adjunctive Therapy to Inpatient Care for Depression
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Depression TreatmentKetamine TherapyPsychiatry
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Depression Treatment
Ketamine Therapy
Psychiatry
A study on the effectiveness of serial ketamine infusions as an adjunctive therapy for depression in inpatient care is discussed, with a focus on its potential therapeutic benefits.
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> Question - For inpatients with moderate to severe depression, is repeated intravenous ketamine superior to a psychoactive placebo (midazolam) in reducing depressive symptoms?
> Findings - In this randomized clinical trial, there was no statistically significant difference in the primary outcome, end-of-treatment Montgomery-Åsberg Depression Rating Scale score, between the ketamine and midazolam groups. No significant differences were observed on secondary efficacy, cognitive, economic, or quality-of-life outcomes.
> Meaning - These findings do not support a superior antidepressant effect for serial intravenous ketamine infusions as an adjunctive therapy to usual inpatient care for moderate to severe depression.