People Who Don't Lose Weight on Wegovy May Have Genetic Differences
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A Scientific American article discusses how people who don't lose weight on Wegovy (a weight loss medication) may have genetic differences that affect the drug's efficacy. The article suggests that individual responses to the medication can vary greatly. Some people may experience significant weight loss, while others may not respond at all. The comments section includes a personal anecdote from someone who has had a mixed response to the medication.
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Nov 28, 2025 at 6:19 PM EST
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I'll have one of two responses:
1. The drug works, and it completely eliminates food noise and the desire to eat unhealthy foods, but I'll get severe side effects (massive diarrhea, vomiting, burps that reek of rotten egg). I lose weight, but a lot of it because I can't keep anything down.
2. The drug doesn't work almost at all. I get minimal effects, and minimal side effects. This is where I am now, I've been consistently going up in dose (incrementally, so I don't trigger the side effects). I'm at 10mg now, and there's minimal effect.
Just mystifying.