Comparing Benefits of Every-Third-Day Vs. Daily Low-Dose Aspirin Therapy (2001)
Key topics
Delving into a 2001 study on aspirin therapy, commenters are weighing the benefits of taking low-dose aspirin every third day versus daily, with some questioning the relevance and reliability of the research. One commenter, abrookewood, points out that taking 325mg every three days is equivalent to triple the daily dose, sparking a discussion on how this might impact side effects. The original poster's clarifications reveal that the study found similar benefits between 81mg daily and every-three-days regimens, with chr15m shedding light on the potential stomach bleed risks associated with platelet inhibition. A follow-up study in 2015 appears to corroborate the initial findings, keeping the conversation lively and relevant.
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Discussion Activity
Moderate engagementFirst comment
38m
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6
2-3h
Avg / period
3.2
Based on 16 loaded comments
Key moments
- 01Story posted
Jan 3, 2026 at 6:10 PM EST
4d ago
Step 01 - 02First comment
Jan 3, 2026 at 6:48 PM EST
38m after posting
Step 02 - 03Peak activity
6 comments in 2-3h
Hottest window of the conversation
Step 03 - 04Latest activity
Jan 4, 2026 at 5:41 AM EST
4d ago
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Daily dose suppressed PGE2 while 3-daily dose didn't.
> Since PGE2 is involved in gastric healing, we understand that this new approach could be safer and as efficient as the standard daily therapy on a long-term basis.
"Acetylsalicylic Acid Daily vs Acetylsalicylic Acid Every 3 Days in Healthy Volunteers: Effect on Platelet Aggregation, Gastric Mucosa, and Prostaglandin E2 Synthesis"
https://accp1.onlinelibrary.wiley.com/doi/abs/10.1002/jcph.6...
I am nearly nine months into NSAID gastritis from only a week of daily 75mg soluble Aspirin.
I have had more painful acute illnesses in the past, but the grind of a long-term illness is new to me and it has been absolutely terrible.