Anti-Aging Injection Regrows Knee Cartilage and Prevents Arthritis

> Human knee tissue collected during joint replacement surgeries also responded positively to the treatment. These samples, which include both the joint’s supporting extracellular scaffolding, or matrix, and cartilage-producing chondrocyte cells, began forming new cartilage that functioned normally.

e.g. https://thefeed.com/products/pillar-performance-collagen-1?v...

https://massresearchreview.com/2025/09/29/connecting-the-dot...

I have been taking collagen, but will likely stop.

> Human knee tissue collected during joint replacement surgeries also responded positively to the treatment. These samples, which include both the joint’s supporting extracellular scaffolding, or matrix, and cartilage-producing chondrocyte cells, began forming new cartilage that functioned normally.

https://www.science.org/action/downloadSupplement?doi=10.112...

It identifies the compound used as SW033291. Searching for it on clinicaltrials.gov gives no hits.

Looking forward to this therapy. My fibrocartilage is wearing out!

Everyone with it I've ever talked to said staying moving is important: "motion is lotion."

My elderly family use lots of anti-inflammatory drugs (NSAIDS) and one of them is on Prednisone.

Two of my friends with rheumatoid arthritis (only in their 30's) are on an injectable immunotherapies (DMARDs) that have been life changing for them.

Disclaimer: not a doctor, just have lots of sore friends/family and an interest in this stuff since I have a torn ACL and fear the future.

On the advice of a massage therapist I instead started a habit of using a home cycling machine for half an hour each morning. So far, it has worked wonders for me, and I hope I can hold on for a decade more, by which time the injection mentioned in the article might be ready for humans.

Two most common types are osteoarthritis (wear-and-tear associated with aging and/or injuries) and rheumatoid arthritis (autoimmune).

I only know about age-related knee osteoarthritis to try to help my mom manage her symptoms, so I'll share my understanding of treating that.

High ROI, low cost: - weight management. Extra lbs are extra stress on the knees, plus I suspect chronic inflammation associated with being overweight can exacerbate arthritis independent of mechanical stress. - exercise, specifically low impact cardio and any pain-free strength/hypertrophy work targeting the musculature around the knees (mainly quads).

Variable ROI, low cost: - NSAIDs, specifically topical to focus on treatment area and reduce impact on GI system/kidneys. - curcumin, mixed evidence but some people report benefits.

Variable ROI, high cost: - PRP injections. Apparently the quality on these varies dramatically by provider. Would recommend doing research and comparing multiple providers if possible. - Knee replacement. Far from a panacea; you'll lose range of motion forever, plus plenty of other trade-offs. Most people recommend putting this off for as long as possible.

Also interesting is low dose radiation treatment for knee OA. More affordable than other procedures and has some promising research.

Not much else on the novel treatment front that I've found. Curious if anyone thinks I've missed anything worthwhile.

If your insurance covers it, go see one! Them being able to actually see and feel what's going on specifically with you makes them markedly better at their jobs.

Not the "I'm going to bench 200lbs" type strength, but the musculature that supports movement.

It's quite easy to always focus on stretching, but not build the muscles that support good movement. You can turn yourself into a floppy noodle, which brings on more injury.

We were told this was because it used to be that they could only do the hip replacement surgery once, and the replacement joint would only last around 20 years max.

So basically it had to be for the expected life span of the patient!

But now this is no longer true. Well, in Australia at least with access to modern replacement parts, surgical techniques and specialists!

I could be muddling it up a bit, so happy to be corrected :-)

10ish years later I had started riding my bike a lot during the dotcom explosion induced downtime, I kept it up after I was employed again. Knee pain came back. Went to the ortho again, this time was told "oh you have a torn meniscus, lets go fix it.

So I went under and woke up to be told that my meniscus was fine, and that I had worn grooves through the cartilage and into the bone - doc told me to never run, jump, ski, ride, etc. I was to sit on the couch.

Somehow I ended up taking karate, and the knees hurt for a bit, but the stretching we did helped loosen up my hams and quads. It didnt make the knee pain go away, but it made it tolerable in that it no longer affected my day to day.

I had a football injury when I was 13 that badly damaged my knee meniscus (though I didn’t know it at that time). At 16, I had a complete menisectomy - total removal of the lateral meniscus in my right knee

I was told that I would need to get a transplant and/or new knees in 10-15 years. I was also told that I shouldn’t put too much strain on the knee

I’m now 38 and my knee is mostly…fine. I can run, squat a reasonable amount of weight, walk for miles. Only thing I can’t do is fast directional changes (like in football) or bending down on the lateral side of my right knee

My plan is to extend this as long as possible and hopefully in 10 years, they’ll have tech to fix this for good

I owe that research group a lot.

I've come to think it's because the trails challenge those stabilizers sufficiently so they get trained properly rather than... I don't know, repeatedly being irritated by running too straight for long periods of time?

I'm not a kinesiologist so I have no idea what the real difference is, but I do know I get hurt far less on the trails than I did on pavement.

One possibility is that I go slower overall so I can't push the limits of some muscle and tendon groups like I could on pavement. Everything gets more equally pressured, but less on average.

I read a book my Michael Colgan at the time, and he mentioned training athletes on the trails as much as possible to reduce injury, so I gave it a try ...

That was 20+ years ago. At first people looked at me strange, like I was running from an animal. But its common now, and I'm still running on the trail, and knees seem OK.

Yes of course, you can still trip, step on a snake, etc, but its a different kind of injury. You are adapting gait and balance constantly which is nice too.

Running on the trail is much more interesting, with constant change, ups, downs, variations. Whereas running on grass / asphalt I can go into autopilot mentally and start ruminating, this is harder on the trail and I am more in a state of "here and now".