Kenvue Stock Drops on Report Rfk Jr Will Link Autism to Tylenol During Pregnancy
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Kenvue's stock drops after RFK Jr's claim that Tylenol during pregnancy is linked to autism, sparking controversy and debate among HN users about the validity of the claim and its potential consequences.
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Until you have a controlled study on pregnant women who use and don't use the drug, you won't really know for sure.
https://news.ki.se/no-link-between-paracetamol-use-during-pr... concludes that there is no link between acetaminophen and autism based on existing research. https://ehjournal.biomedcentral.com/articles/10.1186/s12940-... concludes the opposite. I'm not qualified to determine which of these studies is more reliable, but the evidence is far from clear if multiple literature studies state the opposite conclusion.
News articles seem to state that the conclusions are clear as day but the same websites were equally sure of the opposite last year.
I'll wait or reliable sources of medical information, which the US government no longer is, to comment on these papers rather than assume whatever paper made the HN frontpage last is the final result of the scientific debate.
Obviously what goes into your body should be suspected first, whether it's food, pollutants, or medical interventions.
We don't know the cause of autism. We do know that autism has a heritable component, with significant rates of both siblings having it (which could be explained by environmental factors) and both parent and child having it (which cannot be explained by environmental factors). Surely it would make a lot more sense to suspect a genetic component first?
I wouldn’t look for a prospective randomized controlled trial of this anytime soon. Hard to imagine an IRB approving such a study.
Observational studies do suggest a small but statistically significant association between acetaminophen use in pregnancy and ASD, but the relative risk increase is small, because both the effect size and baseline risk are small.
This is the guy who caught a worm in his brain from eating roadkill?
From a recent meta analysis, a total of 6 studies meeting the inclusion criteria addressed the association between acetaminophen exposure in utero and ASD. The odds ratio for the aggregated data was 1.19 which puts the 0.2-0.4% relative risk increase depending on what baseline incidence you assume (along the lines of your estimate.)
If you take the baseline incidence to be 1% then I calculate the NNH - number needed to harm, at 533, meaning you have to expose 533 pregnant women to acetaminophen to observe one additional case of ASD.
Given that the current public health administration of this era in the U.S. operates by seat-of-the-pants guidance rather than statistical evidence, the statistics are irrelevant to them. My advice would be that health care providers caring for pregnant women have an informed discussion about the risk and call it a day.
1: https://www.scribbr.co.uk/fallacy/the-genetic-fallacy/#:~:te...
And are you really claiming you can't determine that factor by looking?
It puts aside all the big is beautiful and similar takes and points to the fact that many American kids, especially those in certain parts of the country are now afflicted with metabolic syndrome (which is closely associated with mitochondrial disfunction). It is well-known that overloading mitochondria with sugar is quite bad for them and a key contributor to type 2 diabetes.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10036395/ https://pubmed.ncbi.nlm.nih.gov/32428560/ https://pmc.ncbi.nlm.nih.gov/articles/PMC4408906/
You can in fact determine a huge percentage of americans including children are incredibly unhealthy just by looking. Increased focus on exercise and negative incentives on soft drinks and sugary beverages does seem like a major step in the right direction.
If medical facts can reliably be inferred from RFK's statements, by whatever algorithm (i.e. "believe the opposite of whatever he says"), then it follows that he understands what he is talking about. Which would contradict all the evidence I've seen.
And one of the reasons you don't let morons take over your party is that if they ever are right, they won't be believed. If these are actual risks with Tylenol then oops, that take is being lumped in with the antivax hysteria.
Oops for sure. Like if someone says school closures won't have an effect on infection rates, not only will you not be believed, you'll be "anti-science", whatever that means.
I've seen this kind of thing mentioned before. As a non USA person, I don't know what the deal is with RFK and autism. Wasn't it vaccines last month?
But it turns out there may actually be some emerging evidence to support this. This recent Harvard meta-analysis [1] from just last month looked at 46 different studies and suggested that there may actually be something happening here although it's not conclusive. Correlation but not yet causation.
Nobody should be making policy on this yet, but it's the kind of thing that I would allocate some research dollars to if I hadn't just fired all of the competent researchers.
1 - https://hsph.harvard.edu/news/using-acetaminophen-during-pre...
Luckily for those of us who care, there are private and foreign government organizations who still take healthcare and science seriously. Unfortunately the only sane solution seems to be to ignore the US authorities on this for the time being.
Mine was destroyed after they caused a walkout at the CDC.
We are not the same
I mean, he rails against processed food and color/dye additives, some of it being stuff that other countries with reputable FDA-analogues have banned. There could be something to that, even though I can confidently assume his opinions don't come from any sort of scientific rigor.
Some blue states are even (quietly?) jumping on the "MAHA" bandwagon on some issues. Not to categorically say "blue states right, red states wrong", but if your polarized political opponents are putting some of your ideas into practice, maybe not all your ideas are bad, regardless of how unscientifically you may have come by them.
I do not have at all the right background to evaluate this research so treat this opinion for what it's worth, but it seems incautious for the authors to close with this note near the end. People like RFK are looking for an explanation for that 20-fold increase. But the hazard ratios in the studies with positive results seem to be along the lines of 1.05-1.20. They do also note changes in diagnosis criteria before this sentence, but it still seems like if they're going to mention a 20-fold increase, they should be even more explicit that any association with increased Tylenol use could only ever explain a very small part of that.
That means mothers who don't take Tylenol have baseline 3% chance their child will be diagnosed with autism. And mothers who took Tylenol (at the levels of the study) may have a 3.15% to 3.6% chance (assuming causation, which has not been proven).
It seems unlikely we "cracked the code" here.
The best justification for the high increase we're seeing in the data is still just that the data itself has changed in how it's measured and tallied and so on.
Maybe we should. We're talking about pregnant women and autism, along with taking a different painkiller. And if the theory is wrong, it'll only take a few years to find out, presumably.
For people who don't have children: most medical advice regarding pregnant women and infants is overwhelmingly cautious and errs on the side of, "if we don't have enough studies confirming it's 100% safe, it's better to stick to the less questionably safe way." I'm not sure why this would be any different.
The issue here is you need to make a trade. It's not like cutting out alcohol. Now you have to decide, what alternative painkiller will replace it.
There was an initial reason why Tylenol became the standard one, because others were assessed to be riskier in other ways.
I agree with you, people should weight all the known risks from all legitimate studies and data, and base policies around that, and this is no exception.
People are worried though that this won't be the case, and that bias is present from the start in this case, and we might end up making the wrong policy call.
All you’re stating is that you’ve found an echo chamber - which is true of Hacker News (and Reddit, and BlueSky). It’s also true of TruthSocial. I guess my annoyance is that this is Hacker news not DNC news - and as such, I’d hope for more than one (or even two!) perspectives.
I don’t think RFK has shot his credibility - even if he did withdraw from the DNC on October 9, 2023, less than two years ago. His perspective seems stable 20 years on after he wrote “Deadly Immunity” in 2005.
If you think he lost credibility, it wasn’t recent.
I don't find that to be a controversial statement.
[1] https://www.science.org/content/article/trump-officials-down...
Being afforded better care during pregnancy should correlate with better attention (and diagnosis of conditions) to offspring.
If one were cynical one might say this was a good call by Andrea Baccarelli, the Dean of the Faculty, to commission a meta study looking for correlations between common treatments and NDD diagnoses in the current climate of funding going toward whomever can put forward a thread to follow in pursuit of autism.
>> The researchers noted that while steps should be taken to limit acetaminophen use, the drug is important for treating maternal fever and pain, which can also harm children.
also:
>> Baccarelli noted in the “competing interests” section of the paper that he has served as an expert witness for a plaintiff in a case involving potential links between acetominophen use during pregnancy and neurodevelopmental disorders.
Huh, but digging in a little more does show some stronger studies... hmmmm...
https://pmc.ncbi.nlm.nih.gov/articles/PMC6822099/
Yes but that is the whole RFK brand. He and his supporters always try to have their cake and eat it too. Claim something, things go wrong and blame others for misconstruing RFK's comments.
The way this is going - RFK is going to make claims based on this paper and when people get harmed, he and his supporters will claim that people who followed RFK's assertion didn't hear him correctly. He clearly said the policy was based on this paper and people should have done more research and read this paper. See this paper says there is correlation and not causation. So, you cannot blame RFK for this mishap.
EDIT: Indeed it is! The US government is scooby-doo villains? https://www.npr.org/2024/08/05/nx-s1-5063939/rfk-jr-central-...
You may not owe people who you feel are disgusting quacks better, but you owe this community better if you're participating in it.
We live in Cartesian radical subjectivity - and no cogito to save you from the evil demon.
I wouldn’t entirely rule out there being environmental factors, but from the data I could gather it seems that acetaminophen usage has decreased in pregnancy over the last several decades in the US, while autism has increased.
This all seems to go back to the boomer generation believing the world was simpler when they grew up and that it was somehow ruined. That may be true about some things but the reality of their generation is they had no idea what people were going through, and didn’t have the language to describe it
How much are people willing to bet that the incidence of autism will remain unchanged and the administration will disavow everything.
“Nobody knew autism was so complicated.” — future Trump, probably.
"Autism rates have gone down 500% during my r/e/i/g/n/ administration!"
When you go to the doctor because you child is on the spectrum. "Fill out this form Mam", on it is the question "Did you take Tylenol during the pregnancy?"
- You check "Yes" -> Your fault, should have known better. No help for you.
- You check "No" -> Well then it can't be autism, that's "scientifically" proven. No help for you.
Tylenol was introduced in 1955. Autism was first scientifically documented in 1926. If Tylenol causes autism, how did those parents in the 1920s get their hands on it?
Also, wouldn't there been a clear link between Tylenol sales and the occurrence of autism? Where is the data showing that the adoption of Tylenol in the 1960s resulted in a rise in autism, and that the "rise" of autism in the 1990s is linked to an increase in Tylenol use?
The claim is that Tylenol is a factor that increases the risk of autism. It is not the cause of 100% of all cases.
That said, the first synthesis of Paracetamol in the USA was Johns Hopkins in 1877, so maybe the answer is they went to Baltimore.
I remember an old study linking ultrasounds to lefthandedness. It was legit. Families with access to ultrasounds lived in countries/areas where lefthandedness was more culturally accepted, places where it was not drilled out of kids. The study was correct, but anyone touting it as causation was totally incorrect.
Fyi, sharks are way more likely to attack people with australian accents. Never go swimming with an auzzi.
Going back to the top of this thread, I agree that correlation does not mean causation, but in this case, we do not yet even have a justifiable claim of correlation, and RFK Jr. has repeatedly demonstrated his propensity for substituting unfounded opinion and incorrect data for empirical facts, if it suits his agenda.
I wonder whether the political actors in question don't understand correlation != causation, or whether they hope that enough of the populace does not understand it in order to further some goal. But what goal? Buying cheap drug shares? Seems ... silly.
We all know he cannot prove anything, even if Tylenol loses, ensure they cost RFK jr lots of $ in defending himself.
Or is it, perhaps, possible that, if there is indeed a real increase in the rate of autism, it's because of something that has nothing to do with our modern pharmaceuticals?
Could it perhaps be related to the increases in various kinds of air pollution? Water pollution? Pesticides or herbicides in our foods? Or even the dramatic increase in EM signals being broadcast everywhere?
Until there are reputable studies that can actually show something resembling a causal link, getting angry at the medical community, pharmaceutical manufacturers, or vaccine makes for saying they are not responsible is pointless and counterproductive. So far as everyone knows, it really wasn't them.
And while there may be some small subset of people "accusing suffering parents of being crazy", by and large that's also not something that's happening.
There was a marked increase in left-handedness once the 'stigma' of it was removed.
And modern agriculture practices result in lower amounts of less toxic substances in the food supply.
The West is on a decreasing trend of all those kind of pollution since the 70s.
“Or even the dramatic increase in EM signals being broadcast everywhere?”.
It’s funny people are entertaining the hypothesis that EM radiation causes autism in the same conversation where they are trying to assure you that a drug that’s increasingly taken by pregnant women and that is proven to pass the placenta, is 100% harmless and can’t have anything to do with increased levels of autism.
Wrong approach. You prove that something is safe first (and there are ways to do it, one has to creative though) and then have people use it. One does not introduce something in the population and then trying to prove a causal link through stats. There are too many variable and it becomes easy to pass the buck by massaging numbers.
Surely you understand that that makes no sense at all? All of these medicines have already been tested and shown to be safe, based on the science and understanding of the time. That's why they're on the market in the first place.
For better or for worse, the burden of proof is now on those who want to show that they are dangerous.
We are primarily talking about Tylenol. Paracetamol. Acetaminophen.
Perhaps you need to be reminded of the whole sentence you quoted from my post, rather than just the first subclause?
> Until there are reputable studies that can actually show something resembling a causal link, getting angry at the medical community, pharmaceutical manufacturers, or vaccine makes for saying they are not responsible is pointless and counterproductive.
The post I was replying to originally was specifically saying that the medical community needed to be accepting blame for causing autism.
This is bullshit. We do not know what causes autism. We certainly do not have any compelling evidence that anything the medical community is doing is causing autism.
My mistake, I did not quote your original comment correctly.:
I meant to quote:
>Could it perhaps be related to the increases in various kinds of air pollution? Water pollution? Pesticides or herbicides in our foods? Or even the dramatic increase in EM signals being broadcast everywhere?
>This is bullshit. We do not know what causes autism. We certainly do not have any compelling evidence that anything the medical community is doing is causing autism.
I would not put it past them. Harmful until proven otherwise is the approach I would take with most drugs/vaccines in the market out there, today. There is no third party testing for any drug/vaccine today - so pharma is free to manipulate the stats, and they have done it in the past.
Acetaminophen is better studied than like 99% of foods and supplements.
Like cutting funding for autism research [1] and kids with autism on Medicaid [2]?
[1] https://www.disabilityscoop.com/2025/06/02/nih-autism-resear...
[2] https://nebraskaexaminer.com/2025/09/05/nebraska-lawmakers-h...
What? Who is supposedly calling parents of autistic children "crazy"?
True. Infact I'd go so far as to say the medical community causes many of the health problem.
Speaking about empathy most people don't have it, not just the medical community. Even the victims will be victimizers at some point, it's very twisted situation.
( Btw, you have a very obvious pseudonym...)
Paracetamol/acetaminophen (the active ingredient in tylenol) is super toxic to the liver. Lots of people overdose on it, some by accident and some deliberately. As little as FOUR GRAMS can cause jaundice and fuck up your liver. If you have a fever, taking 1 gram every couple of hours might seem entirely reasonable, but it can kill you.
Regardless of any autism links, it's good to be careful with this stuff.
How many other medications would that apply to? Countless, I imagine. That’s why we have dosages on every bottle.
after I had dental surgery, I took paracetamol and ibuprofen in alternate doses every 4h - I would have been in screaming pain if I couldn't have both as an option.
I was recently prescribed 800mg ibuprofen for an injury, where 200mg is the standard OTC dose, and I even questioned that.
when my dad decided to step in, he took her to a doctor to get a full review and confiscate the bag.
It’s like saying jumping on subway tracks when there’s no train is entirely reasonable when there are ample warnings on the platform to not do that.
“ Regardless of any autism links” - there you go again with the innuendo. My dude if you want to warn about how dangerous Tylenol is in and of itself when misused, go right ahead, but leave autism out of it, you’re playing right into the “Tylenol cause autism” fearmonger’s hands.
Why should we feel sorry for the skilled trades again? Mechanics are expert famous scammers worse than lawyer (grandma just replaced her blinker fluid!) That’s just one example. Leak detection companies are nearly all scammers too.
This is very true. ( and no, he is not exaggerating)
Lots of drugs are toxic if misused or abused. Acetaminophen is not unique in that regard.
One gram every 2 hours is 12 grams which is on the lower end of toxic doses.
Despite common belief, concurrent alcohol consumption surprisingly does not increase risk, since alcohol competes for CYP2E1 and reduces the rate of production of the toxic metabolite NAPQI. Similarly for chronic liver disease. The use of NSAIDS (ibuprofen, etc) with cirrhosis is absolutely less safe than tylenol at therapeutic doses.
A person in power makes unsubstantiated (and often disproven claims), and makes major decisions that affect all our lives based on those claims.
And the response ignores the fact that the people in power are making decisions based on complete nonsense and pointing to something fairly trivial that everyone knows about anyways.
I mean, I haven’t been to a doctor who hasn’t pointed out that there are limits to how much acetaminophen one can take. There’s a reason anything above a 650mg dose is prescription only. Theirs is a reason if you’re suffering from a severe fever doctors will give you both acetaminophen and ibuprofen and have you alternate them.
If there is a tiny minority that is apparently unaware of the fact that Tylenol in high doses can have adverse effects or at the very least not even aware of the fact that most medications need to be taken as prescribed or within the suggested limits, that’s a minuscule part of the problem relative to people in power making decisions based on unproven claims.
I don't know how you jumped from "it's dangerous to take in to high amounts, even 4 times the recommended dose is dangerous" to "the recommened dose is dangerous".
When taken correctly it is very safe and had fewer side effects then NSAIDs like ibuprofen.
One could also take a look at pages like cheddar which track what they claim is unusual flow in options.
https://en.wikipedia.org/wiki/Thalidomide_scandal
Tylenol only helps for minor aches and pains that frankly, pregnant mothers should just deal with for the good of their unborn child. The risk is not worth it.
RFK Jr. isn't right on everything, but he's not wrong on everything either and it's refreshing seeing someone head HHS that isn't in big pharma's pocket for a change.
Much better that he be in Big Wellness’s pocket which is an order of magnitude bigger, unregulated, and doesn’t need to provide evidence for their claims.
Please link to some credible sources showing that he's being paid off by someone.
has this ever stopped anybody?
https://nypost.com/2025/01/30/us-news/rfk-jr-in-cash-grab-to...
Untreated symptoms are also bad for the baby, and other OTC painkillers are worse than acetaminophen. You have to become informed and choose the least bad option for your situation (trimester, medical history, etc) rather than let a demagogue point your outrage at a random imperfect solution.
[Citation Needed]
Because there's no clear evidence to the contrary. Research and published papers would be more convincing here than an accusation.
> pregnant mothers should just deal with for the good of their unborn child
There's a number of things they should be restricted from for the good of the child of course, as men request. Blessed be the fruit. /s
Who's to say that the mother experiencing a ton of pain doesnt also affect the fetus?
where's your proof that its safe to leave a prefnant woman in pain?
So 10 times the typical dose is when you have overdose effects. (basically 20 pills per day vs 2 pills per day).
Not your "wildly unsafe at slightly above usage levels" AT ALL (as someone posted on here)
This is not harmless - this might cause someone to take more dangerous painkillers when acetaminophen (tylenol) might have safely helped them. The autism stuff is plainly false and disproved.
I wonder if Americans know how much of their society and culture bled incompletely into other countries via movies. Like for example after communism fell the youth here got hooked on American rap and hip-hop so we were using slang from those songs like friends calling each other the N word without knowing the context behind it since that's how black rappers addressed each other and they were rock stars here.
As with anything, it depends. I'd never heard specifically of your Tylenol example, though I'm generally aware of the idea that (pop-)cultural references often won't be understood when viewed/heard by audiences with different cultural context.
But I think many people in the US just don't think about it, because they don't need to and it never occurs to them. If you told them your story, they'd just think "huh, that's funny; makes sense, but I never thought about it that way".
the unbridled joy when a non american sees a red Solo cup irl for the first time
"i thought it was just a thing in movies!!"
- going after quacks who promote bleach, horse dewormers (maybe that's the problem), and raw milk
- adopt the precautionary principle
- approve EU sunscreen compounds without animal testing and banning reef/human unsafe ones
- leave science to scientists
- increase regulatory oversight over food manufacturing, additive, and supply chain regulation so there aren't canyons of non-enforcement or exclusions between FDA and USDA
Or, maybe, this is really radical... find someone else competent to do the job.
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