Paracetamol Disrupts Early Embryogenesis by Cell Cycle Inhibition

As distinct from the retort that “absence of evidence is not evidence of absence”: It can be, if you’ve tried hard enough to gather the evidence and come up short—which is what these guys have done.

https://hsph.harvard.edu/news/using-acetaminophen-during-pre...

https://ehjournal.biomedcentral.com/articles/10.1186/s12940-...

Okay some don't, particularly North American and Northern/Western European ones.

But mostly, on average, physicians always try to prescribe you something.

"The meta-analysis showed a significant association between maternal tobacco smoking during pregnancy and increased risk of ADHD in offspring."

Mohammadian M, Khachatryan LG, Vadiyan FV, Maleki M, Fatahian F, et al. (2025) The association between maternal tobacco smoking during pregnancy and the risk of attention-deficit/hyperactivity disorder (ADHD) in offspring: A systematic review and meta-analysis. PLOS ONE 20(2): e0317112. https://doi.org/10.1371/journal.pone.0317112

"Compared with unexposed controls, individuals with PAE reported significantly higher frequencies of problems with hearing, dentition, heart, cancer, gastritis, kidney stones, bladder, diabetes, thyroid, skin, and seizures."

Coles, C.D., Shapiro, Z.R., Kable, J.A., Stoner, S.A., Ritfeld, G.J. & Grant, T.M. (2024) Prenatal alcohol exposure and health at midlife: Self-reported health outcomes in two cohorts. Alcohol: Clinical and Experimental Research, 48, 2045–2059. https://doi.org/10.1111/acer.15441

"Our results indicate that perinatal exposure to maternal smoking is associated with increased risks of CVD events, and such relations are modified by adulthood smoking behaviors."

H., Liang, Z., Wang, H., Cardoso, M. A., Heianza, Y., & Qi, L. (2021). Perinatal exposure to maternal smoking and adulthood smoking behaviors in predicting cardiovascular diseases: A prospective cohort study. Atherosclerosis, 328, 52–59. https://doi.org/10.1016/j.atherosclerosis.2021.05.009

"Our findings support previous findings suggesting the detrimental effects of prenatal binge drinking on child cognition. Prenatal alcohol exposure at levels less than daily drinking might be detrimentally associated with child behavior. The results of this review highlight the importance of abstaining from binge drinking during pregnancy and provide evidence that there is no known safe amount of alcohol to consume while pregnant."

Flak, A. L., Su, S., Bertrand, J., Denny, C. H., Kesmodel, U. S., & Cogswell, M. E. (2014). The association of mild, moderate, and binge prenatal alcohol exposure and child neuropsychological outcomes: a meta-analysis. Alcoholism, clinical and experimental research, 38(1), 214–226. https://doi.org/10.1111/acer.12214

You may not not want to hear this, but let's put it plainly: Prenatal smoking and alcohol is clear and obvious child maltreatment.

And the solution is simple: educate people about that.

And it's not something hard to do, just have pharmacists say “respect the dose as it will kill you if you don't” every time they sell things and it'll work.

That is wild.

If true, it would have to be genetic? I mean, unless it is chronic dehydration from their sense of humor?

Oxygen toxicity is not a risk for most people. You either are a scuba diver regularly working at depths beyond what most do or are taking supplemental oxygen while under the care of a doctor. You are not at risk of oxygen toxicity reaching into your bathroom medicine cabinet.

I think the mistakes also come when the child spits out part of the liquid, and parents give another dose.

So if you're going to off yourself you'd have to stock pile or roam around shops picking up.

There is a not insignificant number of suicides where people just say fck it I'll just kill myself but they don't want to go out to any real bother to do it i.e. they don't pre-plan it it's just spur of the moment. A bottle of kill yo self pills is pretty easy. Cupboard, swallow, drink down some water, die. But having to go out and buy a bunch over a few days or like drive around in your car just buying as many as you can. Like you'd have to look it up to check you're going to buy enough.

Back when that law came in when they didn't reduce the total amount you could buy at one time so if you went in and bought like 10 packs at the supermarket then the person at the till would be like ok this person's going to kill themselves so again that would require a bit of balls from the would be kill yo selfer.

I think you can buy a bottle of like 100 x 500mg for like $20 in the USA. That's like over 2 weeks swigging at the max amount. Like you don't need that many, 3-4 days is enough shouldn't be taking that much of the stuff.

Not addictive, not hepatotoxic, not nephrotoxic.

Seems the reason for the ban / harder regulation in some countries is about the disturbance of blood-forming in some individuals (which can also be deadly, but I have no idea of the quantified risk here).

Ibuprofen and acetaminophen are more common for short-term treatment, at least that's what I've been taught.

Avoid taking them on a schedule, take them as needed and at the lowest effective dosage.

A.s.s. (lol) too, apart from the low-dose usage that some claim to be helpful with heart/artery diseases.

No it's not, in many case there's just no way the parent can tell something is about to go wrong.

> Something that has just a 2% incidence should not dictate 98% of the treatments.

This isn't the same argument, and I would agree if it was true, but you're distorting numbers as the actual prevalence estimations lie between 2 and 14%[1].

Now you could make the argument that 10% is low enough of incidence it shouldn't dictate the treatment of the other 90%, but that's not what you're doing, instead you are blaming helpless parents and cherry picking numbers, making nothing but noise.

Oh, and by the way, most parents aren't in fact giving their kids paracetamol for that particular reason (as most parents are simply unaware of the existence of febrile seizures), but to help their children sleep and rest (and so themselves can sleep). And in fact, resting being key in innate immunity efficiency, I'm not particularly convinced about the effectiveness of letting your kids cry all night because of the pain and fever. You do what you want with your own kids, but there's no justification for insulting other parents.

Good day.

[1]: https://www.bmj.com/content/351/bmj.h4240